Dataset Information

Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats.

ABSTRACT:

Background

Cs₂K₄Na [SiW₉Nb₃O₄₀] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications.

Methods

The toxic properties of POM93 were evaluated comprehensively in vivo, including the acute and subchronic oral toxicity studies and genotoxicity tests.

Results

The acute toxicity study showed no abnormal changes or mortality in rats treated with POM93 even at the single high dose of 5000 mg/kg body weight. In the subchronic toxicity study, regardless of the body weight, the organ weight, and the hematological parameters, similar results were observed between the control group and the experimental groups. POM93 produced mild changes in rare hematological parameters in the liver and kidneys, but did not induce the clinical symptoms of liver or kidneys injury in rats as confirmed by histopathological analysis. Moreover, neither mutagenicity nor clastogenicity was caused by POM93 treatment in vitro and in vivo.

Conclusions

The present study demonstrates that the oral administration of POM93 is presumed safe and poses a low risk of potential health risks.

SUBMITTER: Qu X

PROVIDER: S-EPMC5382445 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Publications

Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats.

Qu Xiaofeng X Xu Kun K Zhao Chao C Song Xiuling X Li Jinhua J Li Li L Nie Wei W Bao Hao H Wang Juan J Niu Fenglan F Li Juan J

BMC pharmacology & toxicology 20170405 1

<h4>Background</h4>Cs<sub>2</sub>K<sub>4</sub>Na [SiW<sub>9</sub>Nb<sub>3</sub>O<sub>40</sub>] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other POMs, there is a lack of evidence for in vivo toxicity limits, oral bioavailability, and therapeutic applications.<h4>Methods</h4>The toxic properties of POM93 were evaluated compreh ...[more]

PMID: 28381296

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Project description:Background:Combretum micranthum (CM) (Combretaceae) is widely used in traditional medicine throughout West Africa for the treatment of diabetes, hypertension, inﬂammation, malaria and liver ailments. In our recent research we demonstrated that CM has nephroprotective potentials in diabetes mellitus, hypertension and renal disorders. However, to the best of our knowledge, no systematic study concerning its toxicity proﬁle has been reported. Aim of the study:The study carried out to evaluates the potential toxicity of the hydroalcoholic extract from leaves of the CM, through the method of acute and sub-chronic oral administration in rats. Materials and methods:During the acute toxicity study, male and female rats were orally administrated with CM extract at single doses of 5000 mg/kg (n = 5/group/sex). Abnormal behaviour, toxic symptoms, weight, and death were observed for 14 consecutive days to assess the acute toxicity. For sub-chronic toxicity study, the extract was administered orally at doses of 500 and 1000 mg/kg (n = 5/group/sex) daily to Wistar rats for 28 days. The general behaviour and body weight of the rats was observed daily. A biochemical, haematological, macroscopical and histopathological examinations of several organs were conducted at the end of the treatment period. The CM extract was subjected to Fourier transform infrared spectrophotometric examination in order to detect the presence or absence of cyanide toxic compounds. Results:The absence of absorbance peaks between the 2220-2260 cm-1 region of FT-IR spectrum of CM, indicating the absence of cyanide groups. This suggested that the CM extract may not contain toxic substances. During the acute toxicity test, no mortality or adverse effects were noted at the dose of 5000 mg/kg. In the subchronic study, the CM extract induced no mortality or treatment-related adverse effects with regard to body weight, general behaviour, relative organ weights, hematological, and biochemical parameters. Histopathological examination of vital organs showed normal architecture suggesting no morphological alterations. Conclusion:The present study revealed that oral administration of CM extract for 28 days, at dosage up to 1000 mg/kg did not induce toxicological damage in rats. From acute toxicity study, the median lethal dose (LD50) of the extract was estimated to be more than 5000 mg/kg.

Dataset Information

Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats.

Background

Methods

Results

Conclusions

Publications

Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats.

Similar Datasets

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