Dataset Information

The association of early life socioeconomic conditions with prediabetes and type 2 diabetes: results from the Maastricht study.

ABSTRACT:

Background

Using cross-sectional data from The Maastricht Study, we examined the association of socioeconomic conditions in early life with prediabetes and T2DM in adulthood. We also examined potential mediating pathways via both adulthood socioeconomic conditions and adult BMI and health behaviours.

Methods

Of the 3263 participants (aged 40-75 years), 493 had prediabetes and 906 were diagnosed with T2DM. By using logistic regression analyses, the associations and possible mediating pathways were examined.

Results

Participants with low early life socioeconomic conditions had a 1.56 times higher odds of prediabetes (95% confidence interval (CI)?=?1.21-2.02) and a 1.61 times higher odds of T2DM (95% CI?=?1.31-1.99). The relation between low early life socioeconomic conditions and prediabetes was independent of current socioeconomic conditions (OR?=?1.38, 95% CI?=?1.05-1.80), whereas the relation with T2DM was not independent of current socioeconomic conditions (OR?=?1.10, 95% CI?=?0.87-1.37). BMI party mediated the association between early life socioeconomic conditions and prediabetes.

Conclusions

Socioeconomic inequalities starting in early life were associated with diabetes-related outcomes in adulthood and suggest the usefulness of early life interventions aimed at tackling these inequalities.

SUBMITTER: Derks IP

PROVIDER: S-EPMC5382485 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Publications

The association of early life socioeconomic conditions with prediabetes and type 2 diabetes: results from the Maastricht study.

Derks Ivonne P M IP Koster Annemarie A Schram Miranda T MT Stehouwer Coen D A CD Dagnelie Pieter C PC Groffen Danielle A I DA Bosma Hans H

International journal for equity in health 20170405 1

<h4>Background</h4>Using cross-sectional data from The Maastricht Study, we examined the association of socioeconomic conditions in early life with prediabetes and T2DM in adulthood. We also examined potential mediating pathways via both adulthood socioeconomic conditions and adult BMI and health behaviours.<h4>Methods</h4>Of the 3263 participants (aged 40-75 years), 493 had prediabetes and 906 were diagnosed with T2DM. By using logistic regression analyses, the associations and possible mediati ...[more]

PMID: 28381297

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Project description:Aims/hypothesisType 2 diabetes is a highly heterogeneous disease for which new subgroups ('clusters') have been proposed based on disease severity: moderate age-related diabetes (MARD), moderate obesity-related diabetes (MOD), severe insulin-deficient diabetes (SIDD) and severe insulin-resistant diabetes (SIRD). It is unknown how disease severity is reflected in terms of quality of life in these clusters. Therefore, we aimed to investigate the cluster characteristics and cluster-wise evolution of quality of life in the previously defined clusters of type 2 diabetes.MethodsWe included individuals with type 2 diabetes from the Maastricht Study, who were allocated to clusters based on a nearest centroid approach. We used logistic regression to evaluate the cluster-wise association with diabetes-related complications. We plotted the evolution of HbA1c levels over time and used Kaplan-Meier curves and Cox regression to evaluate the cluster-wise time to reach adequate glycaemic control. Quality of life based on the Short Form 36 (SF-36) was also plotted over time and adjusted for age and sex using generalised estimating equations. The follow-up time was 7 years. Analyses were performed separately for people with newly diagnosed and already diagnosed type 2 diabetes.ResultsWe included 127 newly diagnosed and 585 already diagnosed individuals. Already diagnosed people in the SIDD cluster were less likely to reach glycaemic control than people in the other clusters, with an HR compared with MARD of 0.31 (95% CI 0.22, 0.43). There were few differences in the mental component score of the SF-36 in both newly and already diagnosed individuals. In both groups, the MARD cluster had a higher physical component score of the SF-36 than the other clusters, and the MOD cluster scored similarly to the SIDD and SIRD clusters.Conclusions/interpretationDisease severity suggested by the clusters of type 2 diabetes is not entirely reflected in quality of life. In particular, the MOD cluster does not appear to be moderate in terms of quality of life. Use of the suggested cluster names in practice should be carefully considered, as the non-neutral nomenclature may affect disease perception in individuals with type 2 diabetes and their healthcare providers.

Dataset Information

The association of early life socioeconomic conditions with prediabetes and type 2 diabetes: results from the Maastricht study.

Background

Methods

Results

Conclusions

Publications

The association of early life socioeconomic conditions with prediabetes and type 2 diabetes: results from the Maastricht study.

Similar Datasets

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