Ontology highlight
ABSTRACT:
SUBMITTER: Persico M
PROVIDER: S-EPMC5382535 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20170406
In the present work we performed a combined experimental and computational study on the interaction of the natural antimalarial endoperoxide plakortin and its synthetic analogue 4a with heme. Obtained results indicate that the studied compounds produce reactive carbon radical species after being reductively activated by heme. In particular, similarly to artemisinin, the formation of radicals prone to inter-molecular reactions should represent the key event responsible for Plasmodium death. To ou ...[more]