Ontology highlight
ABSTRACT:
SUBMITTER: Bilham K
PROVIDER: S-EPMC5382539 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Bilham Kirstin K Boyd Amy C AC Preston Stephen G SG Buesching Christina D CD Newman Chris C Macdonald David W DW Smith Adrian L AL
Scientific reports 20170406
The European badger is recognised as a wildlife reservoir for bovine tuberculosis (bTB); the control of which is complex, costly and controversial. Despite the importance of badgers in bTB and the well-documented role for macrophages as anti-mycobacterial effector cells, badger macrophage (bdMφ) responses remain uncharacterised. Here, we demonstrate that bdMφ fail to produce nitric oxide (NO) or upregulate inducible nitric oxide synthase (iNOS) mRNA following Toll-like receptor (TLR) agonist tre ...[more]