Dataset Information

Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer.

ABSTRACT:

Background

Alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2) and the presence of multiple esophageal Lugol-voiding lesions (LVLs; dysplasia) are strong predictors for multiple development of esophageal squamous cell carcinoma (ESCC) in East Asians. We invented a health risk appraisal (HRA) model for predicting the risk of ESCC based on drinking, smoking, dietary habits, and alcohol flushing, i.e., past or present facial flushing after drinking a glass of beer, a surrogate marker for inactive ALDH2.

Methods

Prospective follow-up examinations (median follow-up time, 50.3 months) were performed in 278 Japanese men after endoscopic mucosectomy for early ESCC (UMIN Clinical Trials Registry ID: UMIN000001676).

Results

Sixty-four subjects developed metachronous ESCC. A receiver operating characteristic curve showed that HRA scores ?12 best predicted the development of metachronous ESCC. The ESCC detection rate per 100 person-years was 9.8 in the high-HRA-score group (n = 104) and 4.5 in the low-HRA-score group (n = 174), and the risk of development of metachronous ESCC was higher in the high-HRA-score group than in the low-HRA-score group (adjusted hazard ratio: 2.00 [95% CI: 1.12-3.30]). Multiple LVLs was a very strong predictor of the development of metachronous SCC, but high HRA scores predicted it independently. The cumulative incidences of metachronous ESCC decreased after drinking cessation in the high-HRA-score drinker group (adjusted hazard ratio: 0.37 [0.14-0.97]).

Conclusions

Both the HRA model that included alcohol flushing and the multiple LVL grade predicted the development of metachronous ESCC in Japanese men after endoscopic mucosectomy for ESCC. Drinking cessation in the high-HRA-score drinker group reduced the rate of metachronous ESCC.

SUBMITTER: Yokoyama A

PROVIDER: S-EPMC5383267 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer.

Yokoyama Akira A Katada Chikatoshi C Yokoyama Tetsuji T Yano Tomonori T Kaneko Kazuhiro K Oda Ichiro I Shimizu Yuichi Y Doyama Hisashi H Koike Tomoyuki T Takizawa Kohei K Hirao Motohiro M Okada Hiroyuki H Yoshii Takako T Konishi Kazuo K Yamanouchi Takenori T Tsuda Takashi T Omori Tai T Kobayashi Nozomu N Suzuki Haruhisa H Tanabe Satoshi S Hori Keisuke K Nakayama Norisuke N Kawakubo Hirofumi H Ishikawa Hideki H Muto Manabu M

PloS one 20170406 4

<h4>Background</h4>Alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2) and the presence of multiple esophageal Lugol-voiding lesions (LVLs; dysplasia) are strong predictors for multiple development of esophageal squamous cell carcinoma (ESCC) in East Asians. We invented a health risk appraisal (HRA) model for predicting the risk of ESCC based on drinking, smoking, dietary habits, and alcohol flushing, i.e., past or present facial flushing after drinking a glass of beer, a ...[more]

PMID: 28384229

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Dataset Information

Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer.

Background

Methods

Results

Conclusions

Publications

Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer.

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