Dataset Information

Association between fibromyalgia syndrome and peptic ulcer disease development.

ABSTRACT:

Purpose

The correlation of fibromyalgia syndrome (FMS) with peptic ulcer disease (PUD) is unclear. We therefore conducted a cohort study to investigate whether FMS is correlated with an increased risk of PUD.

Methods

In this study, we established an FMS cohort comprising 26068 patients aged more than 20 years who were diagnosed with FMS from 2000 to 2011. Furthermore, we established a control cohort by randomly choosing 104269 people without FMS who were matched to the FMS patients by gender, age, and index year. All patients were free of PUD at the baseline. Cox proportional hazard regressions were performed to compute the hazard ratio of PUD after adjustment for demographic characteristics and comorbidities.

Results

The prevalence of comorbidities was significantly higher in the FMS patients than in the controls. The incidence of PUD was 29.8 and 19.4 per 1000 person-years in the FMS and control cohorts, respectively. In addition, the FMS cohort exhibited a 1.40-fold higher risk of PUD (95% confidence interval = 1.35-1.45) compared with the control cohort. After control for confounding factors, the medications (selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and antidepressants) taken by the FMS patients did not increase the risk of PUD.

Conclusion

FMS patients exhibit a higher risk of PUD than that of patients without FMS.

SUBMITTER: Wang KA

PROVIDER: S-EPMC5383298 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Association between fibromyalgia syndrome and peptic ulcer disease development.

Wang Kevin A KA Wang Jia-Chi JC Lin Cheng-Li CL Tseng Chun-Hung CH

PloS one 20170406 4

<h4>Purpose</h4>The correlation of fibromyalgia syndrome (FMS) with peptic ulcer disease (PUD) is unclear. We therefore conducted a cohort study to investigate whether FMS is correlated with an increased risk of PUD.<h4>Methods</h4>In this study, we established an FMS cohort comprising 26068 patients aged more than 20 years who were diagnosed with FMS from 2000 to 2011. Furthermore, we established a control cohort by randomly choosing 104269 people without FMS who were matched to the FMS patient ...[more]

PMID: 28384332

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Project description:ObjectivesPeptic ulcer disease (PUD) is a common disorder, but whether an association exists between PUD and anthropometric indicators remains controversial. Furthermore, no studies on the association of PUD with anthropometric indices, blood parameters, and nutritional components have been reported. The aim of this study was to assess associations of anthropometrics, blood parameters, nutritional components, and lifestyle factors with PUD in the Korean population.MethodsData were collected from a nationally representative sample of the South Korean population using the Korea National Health and Nutrition Examination Survey. Logistic regression was used to examine associations of anthropometrics, blood parameters and nutritional components among patients with PUD.ResultsAge was the factor most strongly associated with PUD in women (p = <0.0001, odds ratio (OR) = 0.770 [0.683-0.869]) and men (p = <0.0001, OR = 0.715 [0.616-0.831]). In both crude and adjusted analyses, PUD was highly associated with weight (adjusted p = 0.0008, adjusted OR = 1.251 [95%CI: 1.098-1.426]), hip circumference (adjusted p = 0.005, adjusted OR = 1.198 [1.056-1.360]), and body mass index (adjusted p = 0.0001, adjusted OR = 1.303 [1.139-1.490]) in women and hip circumference (adjusted p = 0.0199, adjusted OR = 1.217 [1.031-1.435]) in men. PUD was significantly associated with intake of fiber (adjusted p = 0.0386, adjusted OR = 1.157 [1.008-1.328], vitamin B2 (adjusted p = 0.0477, adjusted OR = 1.155 [1.001-1.333]), sodium (adjusted p = 0.0154, adjusted OR = 1.191 [1.034-1.372]), calcium (adjusted p = 0.0079, adjusted OR = 1.243 [1.059-1.459]), and ash (adjusted p = 0.0468, adjusted OR = 1.152 [1.002-1.325] in women but not in men. None of the assessed blood parameters were associated with PUD in women, and only triglyceride level was associated with PUD in men (adjusted p = 0.0169, adjusted OR = 1.227 [1.037-1.451]).DiscussionWe found that obesity was associated with PUD in the Korean population; additionally, the association between nutritional components and PUD was greater in women than in men.

Dataset Information

Association between fibromyalgia syndrome and peptic ulcer disease development.

Purpose

Methods

Results

Conclusion

Publications

Association between fibromyalgia syndrome and peptic ulcer disease development.

Similar Datasets

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