Autophagic degradation of focal adhesions underlies metastatic cancer dissemination.
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ABSTRACT:
SUBMITTER: Sharifi MN
PROVIDER: S-EPMC5383354 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Autophagic degradation of focal adhesions underlies metastatic cancer dissemination.
Sharifi Marina N MN Mowers Erin E EE Macleod Kay F KF
Molecular & cellular oncology 20160610 2
Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct interaction with the autophagy protein LC3B is required for focal adhesion disassembly, Src-stimulated tumor cell motility, and metastasis. ...[more]
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