Ontology highlight
ABSTRACT:
SUBMITTER: van Riel WE
PROVIDER: S-EPMC5383399 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
van Riel Wilhelmina E WE Rai Ankit A Rai Ankit A Bianchi Sarah S Katrukha Eugene A EA Liu Qingyang Q Heck Albert Jr AJ Hoogenraad Casper C CC Steinmetz Michel O MO Kapitein Lukas C LC Akhmanova Anna A
eLife 20170314
Microtubules are dynamic polymers that in cells can grow, shrink or pause, but the factors that promote pausing are poorly understood. Here, we show that the mammalian kinesin-4 KIF21B is a processive motor that can accumulate at microtubule plus ends and induce pausing. A few KIF21B molecules are sufficient to induce strong growth inhibition of a microtubule plus end in vitro. This property depends on non-motor microtubule-binding domains located in the stalk region and the C-terminal WD40 doma ...[more]