Ontology highlight
ABSTRACT:
SUBMITTER: Song I
PROVIDER: S-EPMC5383516 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20170227 4
A keystone of antiviral immunity is CD8<sup>+</sup> T cell recognition of viral peptides bound to MHC-I proteins. The recognition modes of individual T cell receptors (TCRs) have been studied in some detail, but the role of TCR variation in providing a robust response to viral antigens is unclear. The influenza M1 epitope is an immunodominant target of CD8<sup>+</sup> T cells that help to control influenza in HLA-A2<sup>+</sup> individuals. Here we show that CD8<sup>+</sup> T cells use many dist ...[more]