Ontology highlight
ABSTRACT:
SUBMITTER: Park S
PROVIDER: S-EPMC5383603 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Park Sunny S Hyun Yang Jin YJ Kim Yu Ran YR Lee Ju Hyun JH Ryu Sunae S Kim Jeong Mi JM Oh Woo Yong WY Na Han Sung HS Lee Jong Gu JG Seo Doo Won DW Hwang In Yeong IY Park Zewon Z Jang In Jin IJ Oh Jaeseong J Choi Seung Eun SE
Journal of Korean medical science 20170501 5
The aim of this study was to examine the effects of CYP2C19*2 and *3 genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses. Twenty-four healthy Korean volunteers were enrolled and given 20 mg omeprazole orally once daily for 8 days. The genotypes of CYP2C19 single nucleotide polymorphisms (SNPs) (*2, *3, and *17) were screened. The plasma concentrations of omeprazole, omeprazole sulfone, and 5-hydroxy (5-OH) omeprazole were determined by liquid chromatograph ...[more]