Ontology highlight
ABSTRACT:
SUBMITTER: Ha TS
PROVIDER: S-EPMC5383633 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Korean journal of pediatrics 20170327 3
Advances in podocytology and genetic techniques have expanded our understanding of the pathogenesis of hereditary steroid-resistant nephrotic syndrome (SRNS). In the past 20 years, over 45 genetic mutations have been identified in patients with hereditary SRNS. Genetic mutations on structural and functional molecules in podocytes can lead to serious injury in the podocytes themselves and in adjacent structures, causing sclerotic lesions such as focal segmental glomerulosclerosis or diffuse mesan ...[more]