Ontology highlight
ABSTRACT:
SUBMITTER: Tapken D
PROVIDER: S-EPMC5384001 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Tapken Daniel D Steffensen Thomas Bielefeldt TB Leth Rasmus R Kristensen Lise Baadsgaard LB Gerbola Alexander A Gajhede Michael M Jørgensen Flemming Steen FS Olsen Lars L Kastrup Jette Sandholm JS
Scientific reports 20170407
Ionotropic glutamate receptors (iGluRs) are responsible for most of the fast excitatory communication between neurons in our brain. The GluD2 receptor is a puzzling member of the iGluR family: It is involved in synaptic plasticity, plays a role in human diseases, e.g. ataxia, binds glycine and D-serine with low affinity, yet no ligand has been discovered so far that can activate its ion channel. In this study, we show that the hinge region connecting the two subdomains of the GluD2 ligand-bindin ...[more]