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Origin and spread of human mitochondrial DNA haplogroup U7.


ABSTRACT: Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (~16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (~11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (~8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.

SUBMITTER: Sahakyan H 

PROVIDER: S-EPMC5384202 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Origin and spread of human mitochondrial DNA haplogroup U7.

Sahakyan Hovhannes H   Hooshiar Kashani Baharak B   Tamang Rakesh R   Kushniarevich Alena A   Francis Amirtharaj A   Costa Marta D MD   Pathak Ajai Kumar AK   Khachatryan Zaruhi Z   Sharma Indu I   van Oven Mannis M   Parik Jüri J   Hovhannisyan Hrant H   Metspalu Ene E   Pennarun Erwan E   Karmin Monika M   Tamm Erika E   Tambets Kristiina K   Bahmanimehr Ardeshir A   Reisberg Tuuli T   Reidla Maere M   Achilli Alessandro A   Olivieri Anna A   Gandini Francesca F   Perego Ugo A UA   Al-Zahery Nadia N   Houshmand Massoud M   Sanati Mohammad Hossein MH   Soares Pedro P   Rai Ekta E   Šarac Jelena J   Šarić Tena T   Sharma Varun V   Pereira Luisa L   Fernandes Veronica V   Černý Viktor V   Farjadian Shirin S   Singh Deepankar Pratap DP   Azakli Hülya H   Üstek Duran D   Ekomasova Trofimova Natalia N   Kutuev Ildus I   Litvinov Sergei S   Bermisheva Marina M   Khusnutdinova Elza K EK   Rai Niraj N   Singh Manvendra M   Singh Vijay Kumar VK   Reddy Alla G AG   Tolk Helle-Viivi HV   Cvjetan Svjetlana S   Lauc Lovorka Barac LB   Rudan Pavao P   Michalodimitrakis Emmanuel N EN   Anagnou Nicholas P NP   Pappa Kalliopi I KI   Golubenko Maria V MV   Orekhov Vladimir V   Borinskaya Svetlana A SA   Kaldma Katrin K   Schauer Monica A MA   Simionescu Maya M   Gusar Vladislava V   Grechanina Elena E   Govindaraj Periyasamy P   Voevoda Mikhail M   Damba Larissa L   Sharma Swarkar S   Singh Lalji L   Semino Ornella O   Behar Doron M DM   Yepiskoposyan Levon L   Richards Martin B MB   Metspalu Mait M   Kivisild Toomas T   Thangaraj Kumarasamy K   Endicott Phillip P   Chaubey Gyaneshwer G   Torroni Antonio A   Villems Richard R  

Scientific reports 20170407


Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (~16-19 thousand years ago) suggests that its current distribution is the consequence of more rece  ...[more]

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