Ontology highlight
ABSTRACT:
SUBMITTER: Morita M
PROVIDER: S-EPMC5384218 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Morita Mayu M Iwasaki Ryotaro R Sato Yuiko Y Kobayashi Tami T Watanabe Ryuichi R Oike Takatsugu T Nakamura Satoshi S Keneko Yosuke Y Miyamoto Kana K Ishihara Kazuyuki K Iwakura Yoichiro Y Ishii Ken K Matsumoto Morio M Nakamura Masaya M Kawana Hiromasa H Nakagawa Taneaki T Miyamoto Takeshi T
Scientific reports 20170407
Various conditions, including bacterial infection, can promote osteonecrosis. For example, following invasive dental therapy with anti-bone resorptive agents, some patients develop osteonecrosis in the jaw; however, pathological mechanisms underlying these outcomes remain unknown. Here, we show that administration of anti-resorptive agents such as the bisphosphonate alendronate accelerates osteonecrosis promoted by infectious osteomyelitis. Potent suppression of bone turnover by these types of a ...[more]