Ontology highlight
ABSTRACT:
SUBMITTER: Bordbar A
PROVIDER: S-EPMC5384226 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Bordbar Aarash A Yurkovich James T JT Paglia Giuseppe G Rolfsson Ottar O Sigurjónsson Ólafur E ÓE Palsson Bernhard O BO
Scientific reports 20170407
The increasing availability of metabolomics data necessitates novel methods for deeper data analysis and interpretation. We present a flux balance analysis method that allows for the computation of dynamic intracellular metabolic changes at the cellular scale through integration of time-course absolute quantitative metabolomics. This approach, termed "unsteady-state flux balance analysis" (uFBA), is applied to four cellular systems: three dynamic and one steady-state as a negative control. uFBA ...[more]