Ontology highlight
ABSTRACT:
SUBMITTER: Eshraghi A
PROVIDER: S-EPMC5384264 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Eshraghi Aria A Kim Jungyun J Walls Alexandra C AC Ledvina Hannah E HE Miller Cheryl N CN Ramsey Kathryn M KM Whitney John C JC Radey Matthew C MC Peterson S Brook SB Ruhland Brittany R BR Tran Bao Q BQ Goo Young Ah YA Goodlett David R DR Dove Simon L SL Celli Jean J Veesler David D Mougous Joseph D JD
Cell host & microbe 20161101 5
The intracellular bacterial pathogen Francisella tularensis causes tularemia, a zoonosis that can be fatal. The type VI secretion system (T6SS) encoded by the Francisella pathogenicity island (FPI) is critical for the virulence of this organism. Existing studies suggest that the complete repertoire of T6SS effectors delivered to host cells is encoded by the FPI. Using a proteome-wide approach, we discovered that the FPI-encoded T6SS exports at least three effectors encoded outside of the island. ...[more]