A review of the importance of immune responses in luminal B breast cancer.
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ABSTRACT:
SUBMITTER: Nelson DJ
PROVIDER: S-EPMC5384410 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
A review of the importance of immune responses in luminal B breast cancer.
Nelson Delia J DJ Clark Briony B Munyard Kylie K Williams Vincent V Groth David D Gill Jespal J Preston Henry H Chan Arlene A
Oncoimmunology 20170119 3
Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules ...[more]
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