Ontology highlight
ABSTRACT:
SUBMITTER: Vannini A
PROVIDER: S-EPMC5385501 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Vannini Andrea A Pinatel Eva E Costantini Paolo Emidio PE Pelliciari Simone S Roncarati Davide D Puccio Simone S De Bellis Gianluca G Peano Clelia C Danielli Alberto A
Scientific reports 20170410
Nickel homeostasis is important for pathogenic and ureolytic bacteria, which use this metal ion as enzymatic cofactor. For example, in the human pathogen Helicobacter pylori an optimal balance between nickel uptake and incorporation in metallo-enzymes is fundamental for colonization of the host. Nickel is also used as cofactor to modulate DNA binding of the NikR regulator, which controls transcription of genes involved in nickel trafficking or infection in many bacteria. Accordingly, there is mu ...[more]