Ontology highlight
ABSTRACT:
SUBMITTER: Shirakabe K
PROVIDER: S-EPMC5385562 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Shirakabe Kyoko K Omura Takuya T Shibagaki Yoshio Y Mihara Emiko E Homma Keiichi K Kato Yukinari Y Yoshimura Akihiko A Murakami Yoshinori Y Takagi Junichi J Hattori Seisuke S Ogawa Yoshihiro Y
Scientific reports 20170410
Ectodomain shedding (shedding) is a post-translational modification, which liberates the extracellular domain of membrane proteins through juxtamembrane processing executed mainly by the ADAM (a disintegrin and metalloprotease) family of metalloproteases. Because shedding alters characteristics of cells in a rapid and irreversible manner, it should be strictly regulated. However, the molecular mechanisms determining membrane protein susceptibility to shedding (shedding susceptibility) are largel ...[more]