Ontology highlight
ABSTRACT:
SUBMITTER: Ren R
PROVIDER: S-EPMC5385610 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Ren Ruotong R Deng Liping L Xue Yanhong Y Suzuki Keiichiro K Zhang Weiqi W Yu Yang Y Wu Jun J Sun Liang L Gong Xiaojun X Luan Huiqin H Yang Fan F Ju Zhenyu Z Ren Xiaoqing X Wang Si S Tang Hong H Geng Lingling L Zhang Weizhou W Li Jian J Qiao Jie J Xu Tao T Qu Jing J Liu Guang-Hui GH
Cell research 20170131 4
Visualization of specific genomic loci in live cells is a prerequisite for the investigation of dynamic changes in chromatin architecture during diverse biological processes, such as cellular aging. However, current precision genomic imaging methods are hampered by the lack of fluorescent probes with high specificity and signal-to-noise contrast. We find that conventional transcription activator-like effectors (TALEs) tend to form protein aggregates, thereby compromising their performance in ima ...[more]