Ontology highlight
ABSTRACT:
SUBMITTER: Xu WD
PROVIDER: S-EPMC5385656 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Natural products and bioprospecting 20160420 3
Catalytic asymmetric formal synthesis of (-)-Triptophenolide and (+)-Triptolide have been achieved. Key reaction involves Palladium catalyzed asymmetric conjugate addition of aryl boronic acid to 3-methyl cyclohexe-1-none to form quaternary carbon. Claisen rearrangement and subsequent aldol reaction furnished trans-decaline key intermediate, which assured a formal total synthesis of (-)-Triptophenolide and (+)-Triptolide. ...[more]