The TAZ-miR-224-SMAD4 axis promotes tumorigenesis in osteosarcoma.
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ABSTRACT:
SUBMITTER: Ma J
PROVIDER: S-EPMC5386375 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
The TAZ-miR-224-SMAD4 axis promotes tumorigenesis in osteosarcoma.
Ma Jianjun J Huang Kangmao K Ma Yan Y Zhou Menglu M Fan Shunwu S
Cell death & disease 20170105 1
Transcriptional co-activator with PDZ-binding motif (TAZ) is a downstream effector of the Hippo signaling pathway that participates in tumorigenesis. The aim of this study was to identify the miRNA counterpart for TAZ and elucidate the mechanism underlying the tumorigenic effect of TAZ. We demonstrated that TAZ is upregulated in osteosarcoma (OS) tissues and cell lines, and that TAZ overexpression can induce cell migration, invasion and proliferation. Moreover, miRNA-224 (miR-224), a TAZ phenoco ...[more]
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