Ontology highlight
ABSTRACT:
SUBMITTER: Tan X
PROVIDER: S-EPMC5386518 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Tan Xin X Chen Shuai S Wu Jiangxue J Lin Jiaxin J Pan Changchuan C Ying Xiaofang X Pan Zhizhong Z Qiu Lin L Liu Ranyi R Geng Rong R Huang Wenlin W
Cell death & disease 20170316 3
Colorectal cancer (CRC) is the third most common cause of cancer deaths, and has a high rate of liver and lung metastasis. Unfortunately, distant metastasis is the main barrier for advanced CRC therapy and leads to a very low survival rate. In this study, we identified WDR5, a vital factor that regulates vertebrate development and cell self-renewal and reprogramming, as a novel prognostic marker and therapeutic target for CRC patients. We demonstrate that WDR5 is upregulated in CRC tissues and p ...[more]