Ontology highlight
ABSTRACT:
SUBMITTER: Lu T
PROVIDER: S-EPMC5386663 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lu Tiantian T Dang Suying S Zhu Rui R Wang Ying Y Nie Zongying Z Hong Tao T Zhang Wei W
Oncotarget 20170301 12
ADAMTS18 is a novel tumor suppressor and is critical to the pathology of human colorectal cancer. However, the underlying mechanism is not clear. Here we generated an Adamts18-deficient mouse strain as an in vivo model to investigate the role of ADAMTS18 in the pathogenesis of colorectal cancer. In AOM/DSS-induced colitis-associated colorectal cancer, the deficiency of Adamts18 in mice resulted in enhanced tumorigenesis and colon inflammation that could be attributed in part to enhanced nuclear ...[more]