Ontology highlight
ABSTRACT:
SUBMITTER: Roscigno G
PROVIDER: S-EPMC5386701 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Roscigno Giuseppina G Puoti Ilaria I Giordano Immacolata I Donnarumma Elvira E Russo Valentina V Affinito Alessandra A Adamo Assunta A Quintavalle Cristina C Todaro Matilde M Vivanco Maria dM MD Condorelli Gerolama G
Oncotarget 20170301 12
Breast cancer remains one of the leading causes of cancer mortality among women. It has been proved that the onset of cancer depends on a very small pool of tumor cells with a phenotype similar to that of normal adult stem cells. Cancer stem cells (CSC) possess self-renewal and multilineage differentiation potential as well as a robust ability to sustain tumorigenesis. Evidence suggests that CSCs contribute to chemotherapy resistance and to survival under hypoxic conditions. Interestingly, hypox ...[more]