Ontology highlight
ABSTRACT:
SUBMITTER: Fan Y
PROVIDER: S-EPMC5386735 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Fan Yao Y Li Haiping H Liang Xiaolong X Xiang Zheng Z
Oncotarget 20170301 12
Heterochromatin protein 1γ (CBX3) links histone methylation marks to transcriptional silence, DNA repair and RNA splicing, but a role for CBX3 in cancer remains largely unknown. In this study, we show that CBX3 in colon cancer cells promotes the progression of the cell cycle and proliferation in vitro and in vivo. Cell cycle (G1 phase to S phase) related gene CDK6 and p21 were further identified as targets of CBX3. In addition, we found that enhancing CDK6 suppresses cell proliferation by upregu ...[more]