Ontology highlight
ABSTRACT:
SUBMITTER: Charbogne P
PROVIDER: S-EPMC5386808 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Charbogne Pauline P Gardon Olivier O Martín-García Elena E Keyworth Helen L HL Matsui Aya A Mechling Anna E AE Bienert Thomas T Nasseef Md Taufiq MT Robé Anne A Moquin Luc L Darcq Emmanuel E Ben Hamida Sami S Robledo Patricia P Matifas Audrey A Befort Katia K Gavériaux-Ruff Claire C Harsan Laura-Adela LA von Elverfeldt Dominik D Hennig Jurgen J Gratton Alain A Kitchen Ian I Bailey Alexis A Alvarez Veronica A VA Maldonado Rafael R Kieffer Brigitte L BL
Biological psychiatry 20161226 9
<h4>Background</h4>Mu opioid receptors (MORs) are central to pain control, drug reward, and addictive behaviors, but underlying circuit mechanisms have been poorly explored by genetic approaches. Here we investigate the contribution of MORs expressed in gamma-aminobutyric acidergic forebrain neurons to major biological effects of opiates, and also challenge the canonical disinhibition model of opiate reward.<h4>Methods</h4>We used Dlx5/6-mediated recombination to create conditional Oprm1 mice in ...[more]