Ontology highlight
ABSTRACT:
SUBMITTER: Boulanger MC
PROVIDER: S-EPMC538702 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Boulanger Marie-Chloé MC Liang Chen C Russell Rodney S RS Lin Rongtuan R Bedford Mark T MT Wainberg Mark A MA Richard Stéphane S
Journal of virology 20050101 1
The human immunodeficiency virus (HIV) transactivator protein, Tat, stimulates transcription from the viral long terminal repeats via an arginine-rich transactivating domain. Since arginines are often known to be methylated, we investigated whether HIV type 1 (HIV-1) Tat was a substrate for known protein arginine methyltransferases (PRMTs). Here we identify Tat as a substrate for the arginine methyltransferase, PRMT6. Tat is specifically associated with and methylated by PRMT6 within cells. Over ...[more]