Nonhepatic cell lines HeLa and 293 support efficient replication of the hepatitis C virus genotype 2a subgenomic replicon.
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ABSTRACT:
SUBMITTER: Kato T
PROVIDER: S-EPMC538706 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
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Nonhepatic cell lines HeLa and 293 support efficient replication of the hepatitis C virus genotype 2a subgenomic replicon.
Kato Takanobu T Date Tomoko T Miyamoto Michiko M Zhao Zijiang Z Mizokami Masashi M Wakita Takaji T
Journal of virology 20050101 1
The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis revealed that mutations in HCV-derived regions were not essential for replication in these cells, as some clones displayed no mutations. ...[more]
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