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Renal function and oxygenation are impaired early after liver transplantation despite hyperdynamic systemic circulation.


ABSTRACT: Acute kidney injury (AKI) occurs frequently after liver transplantation and is associated with the development of chronic kidney disease and increased mortality. There is a lack of data on renal blood flow (RBF), oxygen consumption, glomerular filtration rate (GFR) and renal oxygenation, i.e. the renal oxygen supply/demand relationship, early after liver transplantation. Increased insight into the renal pathophysiology after liver transplantation is needed to improve the prevention and treatment of postoperative AKI. We have therefore studied renal hemodynamics, function and oxygenation early after liver transplantation in humans.Systemic hemodynamic and renal variables were measured during two 30-min periods in liver transplant recipients (n?=?12) and post-cardiac surgery patients (controls, n?=?73). RBF and GFR were measured by the renal vein retrograde thermodilution technique and by renal extraction of Cr-EDTA (= filtration fraction), respectively. Renal oxygenation was estimated from the renal oxygen extraction.In the liver transplant group, GFR decreased by 40% (p?

SUBMITTER: Skytte Larsson J 

PROVIDER: S-EPMC5387193 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Renal function and oxygenation are impaired early after liver transplantation despite hyperdynamic systemic circulation.

Skytte Larsson Jenny J   Bragadottir Gudrun G   Redfors Bengt B   Ricksten Sven-Erik SE  

Critical care (London, England) 20170411 1


<h4>Background</h4>Acute kidney injury (AKI) occurs frequently after liver transplantation and is associated with the development of chronic kidney disease and increased mortality. There is a lack of data on renal blood flow (RBF), oxygen consumption, glomerular filtration rate (GFR) and renal oxygenation, i.e. the renal oxygen supply/demand relationship, early after liver transplantation. Increased insight into the renal pathophysiology after liver transplantation is needed to improve the preve  ...[more]

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