Pan-cancer analysis of systematic batch effects on somatic sequence variations.
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ABSTRACT:
SUBMITTER: Choi JH
PROVIDER: S-EPMC5387285 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Pan-cancer analysis of systematic batch effects on somatic sequence variations.
Choi Ji-Hye JH Hong Seong-Eui SE Woo Hyun Goo HG
BMC bioinformatics 20170411 1
<h4>Background</h4>The Cancer Genome Atlas (TCGA) is a comprehensive database that includes multi-layered cancer genome profiles. Large-scale collection of data inevitably generates batch effects introduced by differences in processing at various stages from sample collection to data generation. However, batch effects on the sequence variation and its characteristics have not been studied extensively.<h4>Results</h4>We systematically evaluated batch effects on somatic sequence variations in pan- ...[more]
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