Structure of the Ebola virus glycoprotein spike within the virion envelope at 11?A resolution.
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ABSTRACT:
SUBMITTER: Beniac DR
PROVIDER: S-EPMC5387728 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Structure of the Ebola virus glycoprotein spike within the virion envelope at 11 Å resolution.
Beniac Daniel R DR Booth Timothy F TF
Scientific reports 20170411
We present the structure of the surface Ebola virus (EBOV) trimeric glycoprotein (GP) spike at 11 Å resolution, in situ within the viral plasma membrane of purified virus particles. GP functions in cellular attachment, endosomal entry, and membrane fusion to initiate infection, and is a key therapeutic target. Nevertheless, only about half of the GP molecule has yet been solved to atomic resolution, excluding the mucin-like and transmembrane domains, and some of the glycans. Fitting of the atomi ...[more]
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