Ontology highlight
ABSTRACT:
SUBMITTER: Laughlin-Toth S
PROVIDER: S-EPMC5388402 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Laughlin-Toth Sarah S Carter E Kathleen EK Ivanov Ivaylo I Wilson W David WD
Nucleic acids research 20170201 3
Specific targeting of protein–nucleic acid interactions is an area of current interest, for example, in the regulation of gene-expression. Most transcription factor proteins bind in the DNA major groove; however, we are interested in an approach using small molecules to target the minor groove to control expression by an allosteric mechanism. In an effort to broaden sequence recognition of DNA-targeted-small-molecules to include both A·T and G·C base pairs, we recently discovered that the hetero ...[more]