Ontology highlight
ABSTRACT:
SUBMITTER: Deng T
PROVIDER: S-EPMC5389484 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Deng Tao T Postnikov Yuri Y Zhang Shaofei S Garrett Lillian L Becker Lore L Rácz Ildikó I Hölter Sabine M SM Wurst Wolfgang W Fuchs Helmut H Gailus-Durner Valerie V de Angelis Martin Hrabe MH Bustin Michael M
Nucleic acids research 20170401 6
An interplay between the nucleosome binding proteins H1 and HMGN is known to affect chromatin dynamics, but the biological significance of this interplay is still not clear. We find that during embryonic stem cell differentiation loss of HMGNs leads to down regulation of genes involved in neural differentiation, and that the transcription factor OLIG2 is a central node in the affected pathway. Loss of HMGNs affects the expression of OLIG2 as well as that of OLIG1, two transcription factors that ...[more]