Ontology highlight
ABSTRACT:
SUBMITTER: Bignon E
PROVIDER: S-EPMC5389527 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Bignon Emmanuelle E Dršata Tomáš T Morell Christophe C Lankaš Filip F Dumont Elise E
Nucleic acids research 20170201 4
Oxidatively-generated interstrand cross-links rank among the most deleterious DNA lesions. They originate from abasic sites, whose aldehyde group can form a covalent adduct after condensation with the exocyclic amino group of purines, sometimes with remarkably high yields. We use explicit solvent molecular dynamics simulations to unravel the structures and mechanical properties of two DNA sequences containing an interstrand cross-link. Our simulations palliate the absence of experimental structu ...[more]