Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC5389560 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Nucleic acids research 20170401 6
The assembly of eukaryotic ribosomes requires numerous factors that transiently associate with evolving pre-ribosomal particles. The Pumilio repeat-containing protein Nop9 briefly associates with the 90S pre-ribosome during its co-transcriptional assembly. Here, we show that Nop9 specifically binds an 11-nucleotide sequence of 18S rRNA that forms the 3΄ side of the central pseudoknot and helix 28 in the mature subunit. Crystal structures of Nop9 in the free and RNA-bound states reveal a new type ...[more]