Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC5389581 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Chen Yali Y Liu Hailong H Zhang Haoxing H Sun Changqing C Hu Zhaohua Z Tian Qingsong Q Peng Changmin C Jiang Pei P Hua Hui H Li Xinzhi X Pei Huadong H
Nucleic acids research 20170301 5
To prevent genomic instability, cells respond to DNA lesions by blocking cell cycle progression and initiating DNA repair. Homologous recombination repair of DNA breaks requires CtIP-dependent resection of the DNA ends, which is thought to play a key role in activation of CHK1 kinase to induce the cell cycle checkpoint. But the mechanism is still not fully understood. Here, we establish that And-1, a replisome component, promotes DNA-end resection and DNA repair by homologous recombination. Mech ...[more]