Ontology highlight
ABSTRACT:
SUBMITTER: Chuartzman SG
PROVIDER: S-EPMC5389645 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
PloS one 20170412 4
Differential signaling of the type I interferon receptor (IFNAR) has been correlated with the ability of its subunit, IFNAR1, to differentially recognize a large spectrum of different ligands, which involves intricate conformational re-arrangements of multiple interacting domains. To shed light onto the structural determinants governing ligand recognition, we compared the force-induced unfolding of the IFNAR1 ectodomain when bound to interferon and when free, using the atomic force microscope an ...[more]