Human population-specific gene expression and transcriptional network modification with polymorphic transposable elements.

ABSTRACT: Transposable element (TE) derived sequences are known to contribute to the regulation of the human genome. The majority of known TE-derived regulatory sequences correspond to relatively ancient insertions, which are fixed across human populations. The extent to which human genetic variation caused by recent TE activity leads to regulatory polymorphisms among populations has yet to be thoroughly explored. In this study, we searched for associations between polymorphic TE (polyTE) loci and human gene expression levels using an expression quantitative trait loci (eQTL) approach. We compared locus-specific polyTE insertion genotypes to B cell gene expression levels among 445 individuals from 5 human populations. Numerous human polyTE loci correspond to both cis and trans eQTL, and their regula

SUBMITTER: Wang L 

PROVIDER: S-EPMC5389732 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature