Ontology highlight
ABSTRACT:
SUBMITTER: Fink KL
PROVIDER: S-EPMC5389739 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Fink Kathren L KL López-Giráldez Francesc F Kim In-Jung IJ Strittmatter Stephen M SM Cafferty William B J WBJ
Cell reports 20170301 11
Functional deficits persist after spinal cord injury (SCI) because axons in the adult mammalian central nervous system (CNS) fail to regenerate. However, modest levels of spontaneous functional recovery are typically observed after trauma and are thought to be mediated by the plasticity of intact circuitry. The mechanisms underlying intact circuit plasticity are not delineated. Here, we characterize the in vivo transcriptome of sprouting intact neurons from Ngr1 null mice after partial SCI. We i ...[more]