A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells.
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ABSTRACT:
SUBMITTER: Stegmann C
PROVIDER: S-EPMC5389858 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells.
Stegmann Cora C Hochdorfer Daniel D Lieber Diana D Subramanian Narmadha N Stöhr Dagmar D Laib Sampaio Kerstin K Sinzger Christian C
PLoS pathogens 20170412 4
Human cytomegalovirus (HCMV) is a widely distributed herpesvirus that causes significant morbidity in immunocompromised hosts. Inhibitors of viral DNA replication are available, but adverse effects limit their use. Alternative antiviral strategies may include inhibition of entry. We show that soluble derivatives of the platelet-derived growth factor receptor alpha (PDGFR-alpha), a putative receptor of HCMV, can inhibit HCMV infection of various cell types. A PDGFR-alpha-Fc fusion protein binds t ...[more]
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