Ontology highlight
ABSTRACT:
SUBMITTER: Espagnolle N
PROVIDER: S-EPMC5390105 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Espagnolle Nicolas N Balguerie Adélie A Arnaud Emmanuelle E Sensebé Luc L Varin Audrey A
Stem cell reports 20170316 4
Mesenchymal stromal cells (MSCs) sense and modulate inflammation and represent potential clinical treatment for immune disorders. However, many details of the bidirectional interaction of MSCs and the innate immune compartment are still unsolved. Here we describe an unconventional but functional interaction between pro-inflammatory classically activated macrophages (M1MΦ) and MSCs, with CD54 playing a central role. CD54 was upregulated and enriched specifically at the contact area between M1MФ a ...[more]