Ontology highlight
ABSTRACT:
SUBMITTER: Rahjouei A
PROVIDER: S-EPMC5390107 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Rahjouei Ali A Pirouz Mehdi M Di Virgilio Michela M Kamin Dirk D Kessel Michael M
Stem cell reports 20170316 4
The chromatin of naive embryonic stem cells (ESCs) has a largely open configuration, as evident by the lack of condensed heterochromatin and the hypomethylation of DNA. Several molecular mechanisms promoting this constellation were previously identified. Here we present evidence for an important epigenetic function of MAD2L2, a protein originally known for its role in DNA damage repair, and for its requirement in germ cell development. We demonstrate using super-resolution microscopy that numero ...[more]