Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5390135 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Li Yaqin Y Cao Jiqing J Chen Menglong M Li Jing J Sun Yiming Y Zhang Yu Y Zhu Yuling Y Wang Liang L Zhang Cheng C
Stem cell reports 20170323 4
Tuberous sclerosis complex (TSC) is a disease featuring devastating and therapeutically challenging neurological abnormalities. However, there is a lack of specific neural progenitor cell models for TSC. Here, the pathology of TSC was studied using primitive neural stem cells (pNSCs) from a patient presenting a c.1444-2A>C mutation in TSC2. We found that TSC2 pNSCs had higher proliferative activity and increased PAX6 expression compared with those of control pNSCs. Neurons differentiated from TS ...[more]