Ontology highlight
ABSTRACT:
SUBMITTER: Moyrand F
PROVIDER: S-EPMC539033 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Moyrand Frédérique F Chang Yun C YC Himmelreich Uwe U Kwon-Chung Kyung J KJ Janbon Guilhem G
Eukaryotic cell 20041201 6
The polysaccharide capsule is the main virulence factor of the basidiomycetous yeast Cryptococcus neoformans. Four genes (CAP10, CAP59, CAP60, and CAP64) essential for capsule formation have been previously identified, although their roles in the biosynthetic pathway remain unclear. A genetic and bioinformatics approach allowed the identification of six CAP64-homologous genes, named CAS3, CAS31, CAS32, CAS33, CAS34, and CAS35, in the C. neoformans genome. This gene family is apparently specific ...[more]