A Systematic Relationship Between Functional Connectivity and Intracortical Myelin in the Human Cerebral Cortex.

ABSTRACT: Research in the macaque monkey suggests that cortical areas with similar microstructure are more likely to be connected. Here, we examine this link in the human cerebral cortex using 2 magnetic resonance imaging (MRI) measures: quantitative  T1 maps, which are sensitive to intracortical myelin content and provide an in vivo proxy for cortical microstructure, and resting-state functional connectivity. Using ultrahigh-resolution MRI at 7 T and dedicated image processing tools, we demonstrate a systematic relationship between T1-based intracortical myelin content and functional connectivity. This effect is independent of the proximity of areas. We employ nonlinear dimensionality reduction to characterize connectivity components and identify specific aspects of functional connectivity that are

SUBMITTER: Huntenburg JM 

PROVIDER: S-EPMC5390400 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature