Ontology highlight
ABSTRACT:
SUBMITTER: Baranzini SE
PROVIDER: S-EPMC539058 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Baranzini Sergio E SE Mousavi Parvin P Rio Jordi J Caillier Stacy J SJ Stillman Althea A Villoslada Pablo P Wyatt Matthew M MM Comabella Manuel M Greller Larry D LD Somogyi Roland R Montalban Xavier X Oksenberg Jorge R JR
PLoS biology 20041228 1
Changes in cellular functions in response to drug therapy are mediated by specific transcriptional profiles resulting from the induction or repression in the activity of a number of genes, thereby modifying the preexisting gene activity pattern of the drug-targeted cell(s). Recombinant human interferon beta (rIFNbeta) is routinely used to control exacerbations in multiple sclerosis patients with only partial success, mainly because of adverse effects and a relatively large proportion of nonrespo ...[more]