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GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci.

ABSTRACT: Understanding the interaction between humans and mosquitoes is a critical area of study due to the phenomenal burdens on public health from mosquito-transmitted diseases. In this study, we conducted the first genome-wide association studies (GWAS) of self-reported mosquito bite reaction size (n?=?84,724), itchiness caused by bites (n?=?69,057), and perceived attractiveness to mosquitoes (n?=?16,576). In total, 15 independent significant (P?

SUBMITTER: Jones AV

PROVIDER: S-EPMC5390679 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci.

Jones Amy V AV Tilley Mera M Gutteridge Alex A Hyde Craig C Nagle Michael M Ziemek Daniel D Gorman Donal D Fauman Eric B EB Chen Xing X Miller Melissa R MR Tian Chao C Hu Youna Y Hinds David A DA Cox Peter P Scollen Serena S

Human molecular genetics 20170401 7

Understanding the interaction between humans and mosquitoes is a critical area of study due to the phenomenal burdens on public health from mosquito-transmitted diseases. In this study, we conducted the first genome-wide association studies (GWAS) of self-reported mosquito bite reaction size (n = 84,724), itchiness caused by bites (n = 69,057), and perceived attractiveness to mosquitoes (n = 16,576). In total, 15 independent significant (P < 5×10-8) associations were identified. These loci were ...[more]

PMID: 28199695

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