Ontology highlight
ABSTRACT:
SUBMITTER: Brown CE
PROVIDER: S-EPMC5390684 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Brown Christine E CE Alizadeh Darya D Starr Renate R Weng Lihong L Wagner Jamie R JR Naranjo Araceli A Ostberg Julie R JR Blanchard M Suzette MS Kilpatrick Julie J Simpson Jennifer J Kurien Anita A Priceman Saul J SJ Wang Xiuli X Harshbarger Todd L TL D'Apuzzo Massimo M Ressler Julie A JA Jensen Michael C MC Barish Michael E ME Chen Mike M Portnow Jana J Forman Stephen J SJ Badie Behnam B
The New England journal of medicine 20161201 26
A patient with recurrent multifocal glioblastoma received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2). Multiple infusions of CAR T cells were administered over 220 days through two intracranial delivery routes - infusions into the resected tumor cavity followed by infusions into the ventricular system. Intracranial infusions of IL13Rα2-targeted CAR T cells were not associated with any toxic effects of grade 3 ...[more]