Breast Cancer Metastasis to the Axillary Lymph Nodes: Are Changes to the Lymph Node "Soil" Localized or Systemic?
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ABSTRACT:
SUBMITTER: Blackburn HL
PROVIDER: S-EPMC5391061 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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Breast Cancer Metastasis to the Axillary Lymph Nodes: Are Changes to the Lymph Node "Soil" Localized or Systemic?
Blackburn Heather L HL Ellsworth Darrell L DL Shriver Craig D CD Ellsworth Rachel E RE
Breast cancer : basic and clinical research 20170210
Metastasis is a multistep process that is not well understood. Colonization of a secondary organ requires specific molecular alterations of the host microenvironment. To determine the temporal and spatial changes associated with metastatic dissemination to the axillary lymph nodes, gene expression profiles were compared between histologically normal lymph nodes from node-positive patients and tumor-free nodes from node-negative patients. Using a stringent false discovery rate correction (<0.05) ...[more]
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